Sulfated modification of the polysaccharide from Cordyceps-gunnii mycelia and its biological activities

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Abstract

A chemically new sulfated polysaccharide (SPS50) was prepared from the water soluble polysaccharide (PS50), isolated from Cordyceps-gunnii mycelia, by concentrated sulfuric acid method. The yield of crude SPS50 was 62.34% and its specific rotation was [α]D20 = -36.75°. The structural characteristics of this chemically sulfated polysaccharide were determined based on the infrared analysis (IR), high performance liquid chromatography (HPLC) and sodium dodecyl sulfate polyacrylamide gel electropheresis (SDS-PAGE). Its biological properties including anti-oxidant and anti-tumor activities were also investigated. The results showed that the anti-oxidant capacity of SPS50 was not as good as SP50 and the anti-tumor activity of SPS50 was much better than PS50. SPS50 showed evident growth inhibition on K562 cells. The tumor inhibition ratio of SPS50 against K562 cells was 69.92%. © 2012 Elsevier Ltd. All rights reserved.

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Zhu, Z. Y., Liu, Y., Si, C. L., Yuan, J., Lv, Q., Li, Y. Y., … Zhang, Y. M. (2013). Sulfated modification of the polysaccharide from Cordyceps-gunnii mycelia and its biological activities. Carbohydrate Polymers, 92(1), 872–876. https://doi.org/10.1016/j.carbpol.2012.10.007

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