The contribution of RBC transfusion to adverse patient outcomes is controversial. There is conflicting clinical data and limited biologic data that provide an underpinning biologic rationale for any adverse impacts from RBC transfusion. This study used in-vitro measures of PMN stimulation to determine the ability of supernatant from RBCs to stimulate allogeneic WBCs and to determine the influence of residual donor WBCs and storage time on the proinflammatory potential of RBCs.
Sparrow, R. L., & Patton, K. A. (2004). Supernatant from stored red blood cell primes inflammatory cells: Influence of prestorage white cell reduction. Transfusion, 44(5), 722–730. https://doi.org/10.1111/j.1537-2995.2004.03113.x