Superselective docetaxel-nedaplatin combined infusion concurrent with radiation therapy in advanced oral cancers

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Abstract

Cisplatin-based superselective intra-arterial chemotherapy concurrent with radiotherapy (SIART) has been reported to be effective in advanced head and neck carcinomas (HNC). However, the ideal regimen has not been established. We combined nedaplatin (CDGP) with docetaxel (DOC) as a new combination in SIART for treatment of advanced oral squamous cell carcinomas (OSCC). Two patients with stage IV advanced OSCC were treated and complete response (CR) were attained, although a residual metastatic lymph node remained in one case. Thirteen and 10months post-treatment, no recurrence or metastatic spread was observed. This result indicated that CDGP and DOC combination in SIART is effective in advanced OSCC treatment. © 2004 Elsevier Ltd. All rights reserved.

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Teh, B. G., Kobayashi, W., Narita, K., Fukui, R., & Kimura, H. (2004). Superselective docetaxel-nedaplatin combined infusion concurrent with radiation therapy in advanced oral cancers. Oral Oncology Extra, 40(10), 126–131. https://doi.org/10.1016/j.ooe.2004.08.002

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