Suppression of HIV-1 transcription by β-chemokines RANTES, MIP1-α, and MIP-1β is not mediated by the NFAT-1 enhancer element

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Abstract

Soluble factors derived from human CD8+ T-lymphocytes inhibit HIV-1 replication by suppressing transcription from the viral long terminal repeat (LTR), an effect shown to be mediated in part by an NFAT-1 enhancer sequence. We show here that the CD8+ derived β-chemokines, RANTES, MIP1-α, and MIP- 1β, known suppressors of HIV-1 replication in human peripheral blood mononuclear cells, can suppress transcription from the HIV-1 LTR in transient transfection assays in cells of the Jurkat (acute T leukemia) line. Surprisingly, the suppression mediated by these β-chemokines persisted in the absence of an intact NFAT-1 element, suggesting that there are at least two classes of HIV-1 suppressor factors -NFAT-1-dependent and NFAT-1- independent factors - produced by CD8+ T-lymphocytes.

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Handen, J. S., & Rosenberg, H. F. (1997). Suppression of HIV-1 transcription by β-chemokines RANTES, MIP1-α, and MIP-1β is not mediated by the NFAT-1 enhancer element. FEBS Letters, 410(2–3), 301–302. https://doi.org/10.1016/S0014-5793(97)00654-6

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