The control by bone metabolism of the blood calcium level in young rats may be described in terms of a regulator-type system. The model presented here comprises a feedback loop involving only a proportional control in thyroparathyroidectomized, and a combination of proportional and integral controls in normal animals. It accounts for the variations observed when the system was subjected to a variety of experimental constraints. The implications, limitations, and possible extensions of the model are discussed. © 1965, The Biophysical Society. All rights reserved.
Aubert, J. P., & Bronner, F. (1965). A Symbolic Model for the Regulation by Bone Metabolism of the Blood Calcium Level in Rats. Biophysical Journal, 5(3), 349–358. https://doi.org/10.1016/S0006-3495(65)86721-2