Using concomitant multimodality optical imaging of synchronized neuronal or astrocytic Ca2+ and hemodynamic changes, Gu et al. show hemodynamic responses to slow sensory stimuli without astrocytic Ca2+ changes. Astrocytic Ca2+ correlates with vasoconstriction after fast stimuli. Neuronal, not astrocytic, slow Ca2+ fluctuations correlate with hemodynamics at rest.
Gu, X., Chen, W., Volkow, N. D., Koretsky, A. P., Du, C., & Pan, Y. (2018). Synchronized Astrocytic Ca2+ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State. Cell Reports, 23(13), 3878–3890. https://doi.org/10.1016/j.celrep.2018.05.091