Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China

  • Zhao Y
  • Song C
  • Ma X
  • et al.
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Abstract

Background . Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. Methods . This was a cross-sectional survey in central urban China ( n=1234 patients with T2DM and n=8615 non-T2DM subjects). The biological interactions, defined by Rothman interactions, between FHD and each dietary factor were analyzed by using the synergy index ( S ) scores. Results . After adjustment for age, gender, BMI, and WHR, a uniparental FHD ( OR=2.84 , 95% CI: 2.36–3.42, P<0.001 ), a paternal history of FHD ( OR=2.53 , 95% CI: 1.91–3.35, P<0.001 ), a maternal history of FHD ( OR=3.27 , 95% CI: 2.67–4.02, P<0.001 ), a biparental history of FHD ( OR=5.26 , 95% CI: 2.98–9.31, P<0.001 ), and a FHD, irrespective of the parent ( OR=3.59 , 95% CI: 3.08–4.17, P<0.001 ), were associated with T2DM onset. There were significant interactions between FHD and consuming <15 g/d of potatoes ( S=1.54 , 95% CI: 1.12–2.12), <8 g/d of poultry ( S=1.51 , 95% CI: 1.04–2.17), <85 g/d of fresh fruits ( S=2.17 , 95% CI: 1.63–2.88), and no freshly squeezed juice ( S=2.25 , 95% CI: 1.46–3.49). Conclusions . Risk of T2DM was synergistically affected by FHD and dietary habits. Nutrition educational intervention may decrease the prevalence of T2DM in the Chinese with FHD.

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Zhao, Y., Song, C., Ma, X., Ma, X., Wang, Q., Ji, H., … Qin, G. (2017). Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China. International Journal of Endocrinology, 2017, 1–8. https://doi.org/10.1155/2017/9707284

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