Targeting Antigens to Dendritic Cell Receptors for Vaccine Development

  • Apostolopoulos V
  • Thalhammer T
  • Tzakos A
  • et al.
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Abstract

Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance. As a consequence of the dual function of DCs, DCs are studied in the context of immunotherapy for both cancer and autoimmune diseases. In vaccine development, a major aim is to induce strong, specific T-cell responses. This is achieved by targeting antigen to cell surface molecules on DCs that efficiently channel the antigen into endocytic compartments for loading onto MHC molecules and stimulation of T-cell responses. The most attractive cell surface receptors, expressed on DCs used as targets for antigen delivery for cancer and other diseases, are discussed.

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Apostolopoulos, V., Thalhammer, T., Tzakos, A. G., & Stojanovska, L. (2013). Targeting Antigens to Dendritic Cell Receptors for Vaccine Development. Journal of Drug Delivery, 2013, 1–22. https://doi.org/10.1155/2013/869718

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