The taste of heavy metals: Gene regulation by MTF-1

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Abstract

The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator involved in cellular adaptation to various stress conditions, primarily exposure to heavy metals but also to hypoxia or oxidative stress. MTF-1 is evolutionarily conserved from insects to humans and is the main activator of metallothionein genes, which encode small cysteine-rich proteins that can scavenge toxic heavy metals and free radicals. MTF-1 has been suggested to act as an intracellular metal sensor but evidence for direct metal sensing was scarce. Here we review recent advances in our understanding of MTF-1 regulation with a focus on the mechanism underlying heavy metal responsiveness and transcriptional activation mediated by mammalian or Drosophila MTF-1. This article is part of a Special Issue entitled: Cell Biology of Metals. © 2011 Elsevier B.V.

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Günther, V., Lindert, U., & Schaffner, W. (2012). The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta - Molecular Cell Research, 1823(9), 1416–1425. https://doi.org/10.1016/j.bbamcr.2012.01.005

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