In contrast to the idea that tau phosphorylation is toxic, Ittner et al. (2016) recently showed that specific tau phosphorylation is neuroprotective, phenocopying tau ablation (DeVos et al., 2017), thus highlighting the complex tau biology that underlies neurotoxicity and neuroprotection.
DeVos, S. L., & Hyman, B. T. (2017, May 17). Tau at the Crossroads between Neurotoxicity and Neuroprotection. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2017.05.001