Tbr1 regulates differentiation of the preplate and layer 6

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Abstract

During corticogenesis, early-born neurons of the preplate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting in a reeler-like cortical migration disorder. Impaired subplate differentiation was associated with ectopic projection of thalamocortical fibers into the basal telencephalon. Layer 6 defects contributed to errors in the thalamocortical, corticothalamic, and callosal projections. These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development.

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Hevner, R. F., Shi, L., Justice, N., Hsueh, Y. P., Sheng, M., Smiga, S., … Rubenstein, J. L. R. (2001). Tbr1 regulates differentiation of the preplate and layer 6. Neuron, 29(2), 353–366. https://doi.org/10.1016/S0896-6273(01)00211-2

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