Recent data indicate that loss of the protective telomeric capping function leads to active degradation of the telomeric G-strand overhang and DNA ligase IV-mediated non-homologous end joining. These molecular events may contribute to genomic instability early in tumorigenesis.
Bertuch, A. A. (2002, October 29). Telomeres: The molecular events driving end-to-end fusions. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)01252-6