Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm

152Citations
Citations of this article
269Readers
Mendeley users who have this article in their library.

Abstract

Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (α) rhythm. However, how the α rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the lateral geniculate nucleus (LGN) that operate in a conventional relay-mode form two groups where the cumulative firing is subject to a cyclic suppression that is centered on the negative α rhythm peak in one group and on the positive peak in the other. This leads to an effective temporal framing of relay-mode output and results from phasic inhibition from LGN interneurons, which in turn are rhythmically excited by thalamocortical neurons that exhibit high-threshold bursts. These results provide a potential cellular substrate for linking the α rhythm to perception and further underscore the central role of inhibition in controlling spike timing during cognitively relevant brain oscillations. © 2009 Elsevier Inc. All rights reserved.

Author supplied keywords

Cite

CITATION STYLE

APA

Lorincz, M. L., Kékesi, K. A., Juhász, G., Crunelli, V., & Hughes, S. W. (2009). Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm. Neuron, 63(5), 683–696. https://doi.org/10.1016/j.neuron.2009.08.012

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free