Th2 and eosinophil responses suppress inflammatory arthritis

26Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

Abstract

Th2-eosinophil immune responses are well known for mediating host defence against h elminths. Herein we describe a function of Th2-eosinophil responses in counteracting the development of arthritis. In two independent models of arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation in the joints associated with robust inhibition of arthritis and protection from bone loss. Mechanistically, this protective effect is dependent on IL-4/IL-13-induced STAT6 pathway. Furthermore, we show that eosinophils play a central role in the modulation of arthritis probably through the increase of anti-inflammatory macrophages into arthritic joints. The presence of these pathways in human disease is confirmed by detection of GATA3-positive cells and eosinophils in the joints of rheumatoid arthritis patients. Taken together, these results demonstrate that eosinophils and helminth-induced activation of the Th2 pathway axis effectively mitigate the course of inflammatory arthritis.

Cite

CITATION STYLE

APA

Chen, Z., Andreev, D., Oeser, K., Krljanac, B., Hueber, A., Kleyer, A., … Bozec, A. (2016). Th2 and eosinophil responses suppress inflammatory arthritis. Nature Communications, 7. https://doi.org/10.1038/ncomms11596

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free