Three-dimensional visualization of forming Hepatitis C virus-like particles by electron-tomography

6Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

Abstract

Hepatitis C virus infects almost 170 million people per year but its assembly pathway, architecture and the structures of its envelope proteins are poorly understood. Using electron tomography of plastic-embedded sections of insect cells, we have visualized the morphogenesis of recombinant Hepatitis C virus-like particles. Our data provide a three-dimensional sketch of viral assembly at the endoplasmic reticulum showing different budding stages and contiguity of buds. This latter phenomenon could play an important role during the assembly of . wt-HCV and explain the size-heterogeneity of its particles. © 2012 Elsevier Inc..

Cite

CITATION STYLE

APA

Badia-Martinez, D., Peralta, B., Andrés, G., Guerra, M., Gil-Carton, D., & Abrescia, N. G. A. (2012). Three-dimensional visualization of forming Hepatitis C virus-like particles by electron-tomography. Virology, 430(2), 120–126. https://doi.org/10.1016/j.virol.2012.05.001

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free