A time to kill: Targeting apoptosis in cancer

135Citations
Citations of this article
220Readers
Mendeley users who have this article in their library.

Abstract

The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.

Author supplied keywords

Cite

CITATION STYLE

APA

Koff, J. L., Ramachandiran, S., & Bernal-Mizrachi, L. (2015, January 28). A time to kill: Targeting apoptosis in cancer. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms16022942

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free