Timescales of Genetic and Epigenetic Inheritance

292Citations
Citations of this article
764Readers
Mendeley users who have this article in their library.

Abstract

According to classical evolutionary theory, phenotypic variation originates from random mutations that are independent of selective pressure. However, recent findings suggest that organisms have evolved mechanisms to influence the timing or genomic location of heritable variability. Hypervariable contingency loci and epigenetic switches increase the variability of specific phenotypes; error-prone DNA replicases produce bursts of variability in times of stress. Interestingly, these mechanisms seem to tune the variability of a given phenotype to match the variability of the acting selective pressure. Although these observations do not undermine Darwin's theory, they suggest that selection and variability are less independent than once thought. © 2007 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Rando, O. J., & Verstrepen, K. J. (2007, February 23). Timescales of Genetic and Epigenetic Inheritance. Cell. https://doi.org/10.1016/j.cell.2007.01.023

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free