The thio-additions of glycals were efficiently promoted by a stoichiometric amount of trimethylsilyl bromide (TMSBr) to produce S-2-deoxyglycosides under solvent-free conditions in good to excellent yields. In addition, with triphenylphosphine oxide as an additive, the TMSBr-mediated direct glycosylations of glycals with a large range of alcohols were highly α-selective.
Hsu, M. Y., Liu, Y. P., Lam, S., Lin, S. C., & Wang, C. C. (2016). TMSBr-mediated solvent- and work-up-free synthesis of α-2-deoxyglycosides from glycals. Beilstein Journal of Organic Chemistry, 12, 1758–1764. https://doi.org/10.3762/bjoc.12.164