Tumor necrosis factor (TNFA) is the canonical member of the TNF superfamily, which plays a major role in both inflammation and apoptosis. To evaluate the role of TNFs in otitis media (OM), the most common disease of childhood, we evaluated middle ear (ME) expression of genes encoding the TNF and TNF receptor superfamilies during bacterial OM in the mouse, characterized OM in TNFA-deficient mice, and assessed apoptosis during OM in normal versus TNF-deficient MEs.
Ebmeyer, J., Leichtle, A., Hernandez, M., Ebmeyer, U., Husseman, J., Pak, K., … Ryan, A. F. (2011). TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC Immunology, 12. https://doi.org/10.1186/1471-2172-12-12