© 2016 Hatai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogenassociated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs: Salmonella and E. coli flagellin FliC and Toxoplasma gondii profilin-like protein. Given the highly divergent biology of these pathogens recognized by TLR11, it is unclear whether common mechanisms are used to recognize these distinct protein PAMPs. Here we show that TLR11 interacts with these two PAMPs using different receptor domains. Furthermore, TLR11 binding to flagellin and profilin exhibits differential dependency on pH and receptor ectodomain cleavage.
Hatai, H., Lepelley, A., Zeng, W., Hayden, M. S., & Ghosh, S. (2016). Toll-like receptor 11 (TLR11) Interacts with flagellin and profilin through disparate mechanisms. PLoS ONE, 11(2). https://doi.org/10.1371/journal.pone.0148987