The trafficking of NaV1.8

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The α-subunit of tetrodotoxin-resistant voltage-gated sodium channel NaV1.8 is selectively expressed in sensory neurons. It has been reported that NaV1.8 is involved in the transmission of nociceptive information from sensory neurons to the central nervous system in nociceptive [1] and neuropathic [24] pain conditions. Thus NaV1.8 has been a promising target to treat chronic pain. Here we discuss the recent advances in the study of trafficking mechanism of NaV1.8. These pieces of information are particularly important as such trafficking machinery could be new targets for painkillers. © 2010 Elsevier Ireland Ltd.




Swanwick, R. S., Pristerá, A., & Okuse, K. (2010, December 10). The trafficking of NaV1.8. Neuroscience Letters.

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