REST/NRSF was first identified as a transcriptional repressor of neuronal genes in non-neuronal cells. Recent studies have now revealed seemingly paradoxical roles for REST/NRSF in neurogenesis, neural plasticity, tumour suppression and cancer progression.
Coulson, J. M. (2005, September 6). Transcriptional regulation: Cancer, neurons and the REST. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2005.08.032