A Transcriptional Signature for Active TB: Have We Found the Needle in the Haystack?

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Abstract

Adithya Cattamanchi and colleagues reflect on recent research by Michael Levin and coworkers into the use of whole blood mRNA expression signatures to detect tuberculosis. The authors highlight challenges faced in getting this promising technology into clinics in low-resource settings. Please see later in the article for the Editors' Summary.

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Cattamanchi, A., Walter, N. D., Metcalfe, J. Z., & Davis, J. L. (2013). A Transcriptional Signature for Active TB: Have We Found the Needle in the Haystack? PLoS Medicine, 10(10). https://doi.org/10.1371/journal.pmed.1001539

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