Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors

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Abstract

Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in carcinogenesis.

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Zientek-Targosz, H., Kunnev, D., Hawthorn, L., Venkov, M., Matsui, S. I., Cheney, R. T., & Ionov, Y. (2008). Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors. Molecular Cancer, 7. https://doi.org/10.1186/1476-4598-7-51

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