Translational applications of microRNAs in cancer, and therapeutic implications

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Abstract

The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therapy or a tool to sensitise patients to treatment modalities such as chemotherapy and radiotherapy. We take a particular perspective towards miRNAs and their impact on rare cancers. Advancement in the delivery of miRNAs, from viral vectors and liposomal delivery to nanoparticle based, has led to a number of pre-clinical and clinical applications for microRNA cancer therapeutics. This is promising, especially in the setting of rare cancers.

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APA

Kwok, G. T., Zhao, J. T., Weiss, J., Mugridge, N., Brahmbhatt, H., MacDiarmid, J. A., … Sidhu, S. B. (2017, September 1). Translational applications of microRNAs in cancer, and therapeutic implications. Non-Coding RNA Research. KeAi Communications Co. https://doi.org/10.1016/j.ncrna.2017.12.002

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