The cloning of full length cDNA for the translocon-associated protein α subunit, previously called signal sequence receptor α, is reported as a result of differential display experiments in search of genes induced by granulocyte-macrophage colony-stimulating factor. Its messenger RNA was more abundant in growing cells than in either factor-deprived cells or quiescent cells and comprised four species, each having microheterogeneity, as a result of complex alternative polyadenylation apparently dependent on arrays of non-canonical polyadenylation signals. Radiation hybrid mapping of the gene showed that the gene is on the short arm of chromosome 6. Copyright (C) 1999 Federation of European Biochemical Societies.
Hirama, T., Miller, C. W., & Koeffler, H. P. (1999). Translocon-associated protein α transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation. FEBS Letters, 455(3), 223–227. https://doi.org/10.1016/S0014-5793(99)00885-6