Transmission model of endemic human malaria in a partially immune population

32Citations
Citations of this article
45Readers
Mendeley users who have this article in their library.

Abstract

A new transmission model of human malaria in a partially immune population with three discrete delays is formulated for variable host and vector populations. These are latent period in the host population, latent period in the vector population and duration of partial immunity. The results of our mathematical analysis indicate that a threshold parameter R0 exists. For R0 > 1, the expected number of mosquitoes infected from humans Rh m should be greater than a certain critical value Rh m* or should be less than Rh m* when Rh m* > 1, for a stable endemic equilibrium to exist. We deduce from model analysis that an increase in the period within which partial immunity is lost increases the spread of the disease. Numerically we deduce that treatment of the partially immune humans assists in reducing the severity of the disease and that transmission blocking vaccines would be effective in a partially immune population. Numerical simulations support our analytical conclusions and illustrate possible behaviour scenarios of the model. © 2007 Elsevier Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Chiyaka, C., Garira, W., & Dube, S. (2007). Transmission model of endemic human malaria in a partially immune population. Mathematical and Computer Modelling, 46(5–6), 806–822. https://doi.org/10.1016/j.mcm.2006.12.010

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free