The feasibility of a one pot approach for conducting mutually orthogonal thiol-Michael addition, copper catalyzed azide-alkyne and inverse electron demand Diels-Alder click chemistry on a tri-functional substrate was demonstrated.
Knall, A. C., Hollauf, M., Saf, R., & Slugovc, C. (2016). A trifunctional linker suitable for conducting three orthogonal click chemistries in one pot. Organic and Biomolecular Chemistry, 14(45), 10576–10580. https://doi.org/10.1039/c6ob02182d