Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials

  • Amos K
  • Adamo B
  • Anders C
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Abstract

Triple-negative breast cancer (TNBC) is an aggressive malignancy with a poor prognosis despite the high rates of response to chemotherapy. This scenario highlights the need to develop novel therapies and/or treatment strategies to reduce the mortality associated with TNBC. The neoadjuvant setting provides a model for rapid assessment of treatment efficacy with smaller patient accruals and over shorter periods of time compared to the traditional adjuvant setting. In addition, a clear surrogate endpoint of improved survival, known as pathologic complete response, already exists in this setting. Here, we review current data from completed and ongoing neoadjuvant clinical trials for TNBC.

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Amos, K. D., Adamo, B., & Anders, C. K. (2012). Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials. International Journal of Breast Cancer, 2012, 1–7. https://doi.org/10.1155/2012/385978

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