A truncated PPAR gamma 2 localizes to mitochondria and regulates mitochondrial respiration in brown adipocytes

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Abstract

Peroxisome proliferator-activated receptor gamma {(PPARγ)} is a key regulator of brown adipocyte differentiation and thermogenesis. The {PPARγ} gene produces two isoforms, {PPARγ1} and {PPARγ2.} {PPARγ2} is identical to {PPARγ1} except for additional 30 amino acids present in the N-terminus of {PPARγ2.} Here we report that the C-terminally truncated form of {PPARγ2} is predominantly present in the mitochondrial matrix of brown adipocytes and that it binds to the D-loop region of mitochondrial {DNA} {(mtDNA),} which contains the promoter for mitochondrial electron transport chain {(ETC)} genes. Expression of mitochondrially targeted {MLS-PPARγ2} in brown adipocytes increases {mtDNA-encoded} {ETC} gene expression concomitant with enhanced mitochondrial respiration. These results suggest that direct regulation of mitochondrially encoded {ETC} gene expression by mitochondrial {PPARγ2,} in part, underlies the isoform-specific role for {PPARγ2} in brown adipocytes.

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APA

Chang, J. S., & Ha, K. (2018). A truncated PPAR gamma 2 localizes to mitochondria and regulates mitochondrial respiration in brown adipocytes. PLoS ONE, 13(3). https://doi.org/10.1371/journal.pone.0195007

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