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Immunity against Mycobacterium tuberculosis relies on complex mechanisms and inhalation of droplets containing Mycobacterium tuberculosis rarely provides active tuberculosis. Positivity of tuberculin skin test (TST) and/or interferon gamma release assay (IGRAs) stands for latent Mycobacterium tuberculosis infection (LTBI). The higher specificity of the IGRAs compared to TST, especially in BCG-vaccinated people is clearly established. The studies also demonstrate the good negative predictive value of the IGRAs concerning the progression to active tuberculosis in immunucompetent adults. In immunocompromised patients, IGRAs capacity to diagnostic LTBI does not seem to be superior than tha of TST. At this point, IGRAs -as TST- are not able to distinguish between a recent or an old LTBI. © 2012 Société de Pneumologie de Langue Française (SPLF).




Bouvry, D. (2012). Tuberculose. Revue Des Maladies Respiratoires Actualites, 4(1), 34–37.

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