Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC

  • DeClerck Y
  • Hung L
  • Shimada H
  • et al.
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Abstract

Abstract Tumor-associated macrophages {(TAMs)} are strongly associated with poor survival in neuroblastomas that lack {MYCN} amplification. To study {TAM} action in neuroblastomas, we used a novel murine model of spontaneous neuroblastoma lacking {MYCN} amplification, and observed recruitment and polarization of {TAMs,} which in turn enhanced neuroblastoma proliferation and growth. In both murine and human neuroblastoma cells, we found that {TAMs} increased {STAT3} activation in neuroblastoma cells and transcriptionally up-regulated

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DeClerck, Y. A., Hung, L. T., Shimada, H., Nakata, R., Muthugounder, S., Shirinbak, S., … Asgharzadeh, S. (2017). Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC. Oncotarget, 8(53), 91516–91529. https://doi.org/10.18632/oncotarget.21066

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