91Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Dietary spice components have been screened for their protective effect against reactive oxygen species (ROS)-induced, lipid peroxide-mediated membrane and DNA damage and mutagenecity. A new, water soluble, 5-kDa peptide-Turmerin-from turmeric (Curcuma longa) has been found to be an efficient antioxidant/DNA-protectant/antimutagen. Turmerin forms 0.1% of the dry weight of turmeric and is obtained in a crystalline form. It is a heat stable, noncyclic peptide containing 40 amino acid residues, with a blocked N-terminal and leucine at the C-terminal. It is insensitive to trypsin and pepsin, heat, and uv radiation. Turmerin contains three residues of methionine which are partly responsible for the antioxidant activity. Turmerin at 183 nm offers 80% protection to membranes and DNA against oxidative injury. ROS-induced arachidonate release and the mutagenic activity of t-butyl hydroperoxide are substantially inhibited by Turmerin. Turmerin is noncytotoxic up to milligram concentrations, as tested by Ames assay and in human lymphocytes. © 1992.

Cite

CITATION STYLE

APA

Srinivas, L., Shalini, V. K., & Shylaja, M. (1992). Turmerin: A water soluble antioxidant peptide from turmeric [Curcuma longa]. Archives of Biochemistry and Biophysics, 292(2), 617–623. https://doi.org/10.1016/0003-9861(92)90040-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free