Two acidic, anticoagulant PLA2 isoenzymes purified from the venom of monocled cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor Xa via phospholipids independent, non-enzymatic mechanism

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Abstract

The monocled cobra {(Naja} kaouthia) is responsible for snakebite fatality in Indian subcontinent and in south-western China. Phospholipase A2 {(PLA2;} {EC} 3.1.1.4) is one of the toxic components of snake venom. The present study explores the mechanism and rationale(s) for the differences in anticoagulant potency of two acidic {PLA2} isoenzymes, {Nk-PLA2α} (13463.91 Da) and {Nk-PLA2β} (13282.38 Da) purified from the venom of N. kaouthia.

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Mukherjee, A. K., Kalita, B., & Thakur, R. (2014). Two acidic, anticoagulant PLA2 isoenzymes purified from the venom of monocled cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor Xa via phospholipids independent, non-enzymatic mechanism. PLoS ONE, 9(8). https://doi.org/10.1371/journal.pone.0101334

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