A two- versus three-embryo transfer: The oocyte donation model

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Objective: To compare implantation and pregnancy rates in oocyte recipients undergoing a two-embryo versus three-embryo transfer, 3 days after retrieval. Design: Retrospective comparative analysis. Setting: University-based in vitro fertilization center.Patient(s): All oocyte recipients undergoing embryo transfer from January 1, 1997 through August 31, 1999. Intervention(s): Recipients received two or three embryos. Main Outcome Measure(s): Implantation, and clinical and multiple pregnancy rates. Result(s): Seventy-three recipients underwent a two-embryo transfer, and 376 had three embryos replaced. The numbers of oocytes retrieved (12.7 ± 0.89 vs. 13.1 ± 0.36) and embryos obtained (8.05 ± 0.65 vs. 8.77 ± 0.27) did not differ between the two-embryo and three-embryo transfer groups, nor did the proportion of patients with embryo cryopreservation (54.3% vs. 42.6%, respectively). There was no significant difference in pregnancy or implantation rates when comparing those patients with a two-embryo transfer to those with a three-embryo transfer. Significantly, 13.8% of the pregnancies in the three-embryo transfer group were triplet. Conclusion(s): Reducing the number of embryos transferred in an oocyte donation cycle can lower the incidence of triplet pregnancies without significantly lowering the overall pregnancy rate. Copyright © 2001 American Society for Reproductive Medicine.




Licciardi, F., Berkeley, A. S., Krey, L., Grifo, J., & Noyes, N. (2001). A two- versus three-embryo transfer: The oocyte donation model. Fertility and Sterility, 75(3), 510–513. https://doi.org/10.1016/S0015-0282(00)01755-6

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