Unusual flavoenzyme catalysis in marine bacteria

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Ever since the discovery of the flavin cofactor more than 80 years ago, flavin-dependent enzymes have emerged as ubiquitous and versatile redox catalysts in primary metabolism. Yet, the recent advances in the discovery and characterization of secondary metabolic pathways exposed new roles for flavin-mediated catalysis in the generation of structurally complex natural products. Here, we review a selection of key biosynthetic flavoenzymes from marine bacterial secondary metabolism and illustrate how their functional and mechanistic investigation expanded our view of the cofactor's chemical repertoire and led to the discovery of a previously unknown flavin redox state.




Teufel, R., Agarwal, V., & Moore, B. S. (2016, April 1). Unusual flavoenzyme catalysis in marine bacteria. Current Opinion in Chemical Biology. Elsevier Ltd. https://doi.org/10.1016/j.cbpa.2016.01.001

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