Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, reinforcing interest in their clinical development.
Gorin, J. B., Guilloux, Y., Morgenstern, A., Chérel, M., Davodeau, F., & Gaschet, J. (2014). Using α radiation to boost cancer immunity? OncoImmunology, 3(9). https://doi.org/10.4161/21624011.2014.954925