Background The obesity epidemic has significantly increased the incidence and severity of hepatic steatosis in liver surgery patients and liver donors, potentially impacting postoperative liver regeneration and function. Development of a non-invasive means to quantify hepatic steatosis would facilitate selection of candidates for liver resection and transplant donation. Methods An IRB-approved protocol prospectively enrolled 28 patients with liver tumors requiring hepatic resection. In all patients, fast dual-echo gradient-echo MR images were acquired using 2-Point Dixon technique in 2D and 3D. The degree of steatosis was quantified by percent fat fraction (%FF) from in- and out-of-phase, and water-only and fat-only images. The technique-specific %FFs were compared to intraoperative and histopathological findings. Results For patients with >30% steatosis by histology, the mean %FF was 22% (SD ± 5.2%) compared to a mean %FF of 5.0% (SD ± 2.1%, p = 0.0001) in patients with <30% steatosis. Using scaled values for the MR-calculated %FF, all patients with >30% pathologic steatosis could be identified preoperatively. Conclusions Quantitative MRI identified patients with clinically-relevant steatosis with 100% accuracy. These findings could have significant impact on the management of liver resection patients and transplant donors.
C.N., C., H., C., P., H., C.H., D., J., M., A., R., … T.A., A. (2017). Using MRI to non-invasively and accurately quantify preoperative hepatic steatosis. HPB, 19(8), 706–712. https://doi.org/10.1016/j.hpb.2017.04.009 LK - http://limo.libis.be/resolver?&sid=EMBASE&issn=14772574&id=doi:10.1016%2Fj.hpb.2017.04.009&atitle=Using+MRI+to+non-invasively+and+accurately+quantify+preoperative+hepatic+steatosis&stitle=HPB&title=HPB&volume=19&issue=8&spage=706&epage=712&aulast=Clarke&aufirst=Callisia+N.&auinit=C.N.&aufull=Clarke+C.N.&coden=HPBIF&isbn=&pages=706-712&date=2017&auinit1=C&auinitm=N.