Abstract

Background The obesity epidemic has significantly increased the incidence and severity of hepatic steatosis in liver surgery patients and liver donors, potentially impacting postoperative liver regeneration and function. Development of a non-invasive means to quantify hepatic steatosis would facilitate selection of candidates for liver resection and transplant donation. Methods An IRB-approved protocol prospectively enrolled 28 patients with liver tumors requiring hepatic resection. In all patients, fast dual-echo gradient-echo MR images were acquired using 2-Point Dixon technique in 2D and 3D. The degree of steatosis was quantified by percent fat fraction (%FF) from in- and out-of-phase, and water-only and fat-only images. The technique-specific %FFs were compared to intraoperative and histopathological findings. Results For patients with >30% steatosis by histology, the mean %FF was 22% (SD ± 5.2%) compared to a mean %FF of 5.0% (SD ± 2.1%, p = 0.0001) in patients with <30% steatosis. Using scaled values for the MR-calculated %FF, all patients with >30% pathologic steatosis could be identified preoperatively. Conclusions Quantitative MRI identified patients with clinically-relevant steatosis with 100% accuracy. These findings could have significant impact on the management of liver resection patients and transplant donors.

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APA

C.N., C., H., C., P., H., C.H., D., J., M., A., R., … T.A., A. (2017). Using MRI to non-invasively and accurately quantify preoperative hepatic steatosis. HPB, 19(8), 706–712. https://doi.org/10.1016/j.hpb.2017.04.009 LK  - http://limo.libis.be/resolver?&sid=EMBASE&issn=14772574&id=doi:10.1016%2Fj.hpb.2017.04.009&atitle=Using+MRI+to+non-invasively+and+accurately+quantify+preoperative+hepatic+steatosis&stitle=HPB&title=HPB&volume=19&issue=8&spage=706&epage=712&aulast=Clarke&aufirst=Callisia+N.&auinit=C.N.&aufull=Clarke+C.N.&coden=HPBIF&isbn=&pages=706-712&date=2017&auinit1=C&auinitm=N.

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