Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
Crispin, M., Harvey, D. J., Bitto, D., Halldorsson, S., Bonomelli, C., Edgeworth, M., … Bowden, T. A. (2014). Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome. Journal of Virology, 88(17), 10244–10251. https://doi.org/10.1128/jvi.01662-14