Immunization against angiogenic-associated antigens selectively expressed on tumor vasculature provides for a novel strategy to block tumor growth.The feasibility of this approach has recently been borne out in several reports demonstrating that the protein or DNA of angiogenic molecules, such as VEGF-R2, can be used as vaccines to generate an effective cytotoxic T cell and antibody response against tumor vessels, thereby blocking tumor growth and metastasis.
Rafii, S. (2002). Vaccination against tumor neovascularization: Promise and reality. Cancer Cell. Cell Press. https://doi.org/10.1016/S1535-6108(02)00208-8