Validated RP-HPLC method for analysis of aripiprazole in a formulation

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A rapid, simple and validated reversed-phase high-performance liquid chromatographic method has been developed for analysis of aripiprazole in tablet dosage form. Aripiprazole was separated on an ODS analytical column with a 40:60 (v/v) mixture of acetonitrile and triethanolamine buffer (5 mM, pH 3.5 ± 0.05 adjusted by addition of 85% phosphoric acid) as mobile phase at a flow rate of 1.5 mL -1. The effluent was monitored by UV detection at 254 nm. Calibration plots were linear in the range of 20 to 60 μg mL-1 and the LOD and LOQ were 0.411 and 1.248 μg mL-1, respectively. The high recovery and low relative standard deviation confirm the suitability of the method for routine quality control determination of aripiprazole in tablets.




Kalaichelvi, R., Thangabalan, B., & Srinivasa Rao, D. (2010). Validated RP-HPLC method for analysis of aripiprazole in a formulation. E-Journal of Chemistry, 7(3), 827–832.

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