Validated RP-HPLC method for analysis of aripiprazole in a formulation

6Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

A rapid, simple and validated reversed-phase high-performance liquid chromatographic method has been developed for analysis of aripiprazole in tablet dosage form. Aripiprazole was separated on an ODS analytical column with a 40:60 (v/v) mixture of acetonitrile and triethanolamine buffer (5 mM, pH 3.5 ± 0.05 adjusted by addition of 85% phosphoric acid) as mobile phase at a flow rate of 1.5 mL -1. The effluent was monitored by UV detection at 254 nm. Calibration plots were linear in the range of 20 to 60 μg mL-1 and the LOD and LOQ were 0.411 and 1.248 μg mL-1, respectively. The high recovery and low relative standard deviation confirm the suitability of the method for routine quality control determination of aripiprazole in tablets.

Cite

CITATION STYLE

APA

Kalaichelvi, R., Thangabalan, B., & Srinivasa Rao, D. (2010). Validated RP-HPLC method for analysis of aripiprazole in a formulation. E-Journal of Chemistry, 7(3), 827–832. https://doi.org/10.1155/2010/935279

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free