We analyzed the transcriptional regulation of the putative virulence genes encoded on the plasmid pCP13 from Clostridium perfringens strain 13. The transcription of the beta2-toxin (cpb2) and possible collagen adhesin (cna) genes were regulated in both a positive and negative manner, respectively, by the two-component VirR/VirS system. The secondary regulator of the VirR/VirS system, VR-RNA, also affects the expression of both of these genes in the same fashion as the VirR/VirS system. This indicates that the global regulatory cascade of the VirR/VirS system controls the expression of virulence genes located on the plasmid, as well as those found chromosomally in C. perfringens strain 13. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.
Ohtani, K., Kawsar, H. I., Okumura, K., Hayashi, H., & Shimizu, T. (2003). The VirR/VirS regulatory cascade affects transcription of plasmid-encoded putative virulence genes in Clostridium perfringens strain 13. FEMS Microbiology Letters, 222(1), 137–141. https://doi.org/10.1016/S0378-1097(03)00255-6