In vitro, evaluation of medicinal activity of egyptian honey from different floral sources as anticancer and antimycotic infective agents

Abstract

The anticancer and antimycotic activity of crude and extracted honey samples of three different Egyptian floral sources (Cassia javanica, Citrus reticulata and Ziziphus spina-Christi) against colon, breast and liver tumor cell line (HCT-116, HTB-26 and HepG2) and over clinical dermatophytes (Tricophyton, Microsporum and Epidermophyton), which are involved in dermatomycosis and dermatophytosis including cutaneous infections in cancer patient were evaluated in vitro study. Cassia honey showed antifungal activity against Epidermophyton and Microsporum species with inhibition zone ranged from 15 to 28 mm and it showed moderate cytotoxic activity against colon and breast cancer with the weakest cytotoxic activity against liver cancer. Crude Citrus honey exhibited potent antimycotic activity against Tricophyton species with inhibition zone ranged from 22 to 35 mm in diameter and the highest cytotoxic activity against breast cancer with growth inhibition of 99.4 ± 0.4 %. However crude Ziziphus honey provided the largest average inhibition zone diameter against all dermatophytes species which were ranged from 29 to 43 mm as well as it display potent efficiency against colon, liver and breast cancer with tumor growth suppression of 100 ± 0.1, 99.2 ± 0.4 and 88.14 ± 0.1 %. The Maximum extractive bioactive agents, anticancer and antimycotic substances, were detected with ethyl acetate or acetone extract, while the minimum were detected with methanol or chloroform extract. © 2010 El-Gendy MMA.