In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis

  • McNeil M
  • Dennison D
  • Shelton C
  • et al.
N/ACitations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA ( rrl ). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that may limit spread in clinical settings.

Cite

CITATION STYLE

APA

McNeil, M. B., Dennison, D. D., Shelton, C. D., & Parish, T. (2017). In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis . Antimicrobial Agents and Chemotherapy, 61(10). https://doi.org/10.1128/aac.01296-17

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free