Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA ( rrl ). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that may limit spread in clinical settings.
McNeil, M. B., Dennison, D. D., Shelton, C. D., & Parish, T. (2017). In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis . Antimicrobial Agents and Chemotherapy, 61(10). https://doi.org/10.1128/aac.01296-17