A water soluble tri-cationic porphyrin-EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines

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Abstract

In this study, a completely water soluble tri-cationic porphyrin-EDTA conjugate was synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble cationic porphyrin TMPy 3PhenEDTA-P-Cl 4 in the dark, in the medullary thyroid carcinoma cell lines MTC-SK and SHER-I and weaker effects in the small intestinal neuroendocrine tumor cell line KRJ-I. In addition, cytotoxic effects were also studied in normal human fibroblasts that represent normal tissue and the results are compared to the tumor cell lines. © 2011 Elsevier Inc. All rights reserved.

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Schwach, G., Thamyongkit, P., Reith, L. M., Svejda, B., Knör, G., Pfragner, R., & Schoefberger, W. (2012). A water soluble tri-cationic porphyrin-EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines. Bioorganic Chemistry, 40(1), 108–113. https://doi.org/10.1016/j.bioorg.2011.09.006

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