Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis

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Abstract

There is a need for new safe, effective and short-course treatments for leishmaniasis; one strategy is to use combination chemotherapy. Polymer-drug conjugates have shown promise for the delivery of anti-leishmanial agents such as amphotericin B. In this paper, we report on the preparation and biological evaluation of polymer-drug conjugates of N-(2-hydroxypropyl)methacrylamide (HPMA), amphotericin B and alendronic acid. The combinatorial polymer-drug conjugates were effective anti-leishmanial agents in vitro and in vivo, but offered no advantage over the single poly(HPMA)-amphotericin B conjugates. © 2010 Elsevier Ltd. All rights reserved.

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Nicoletti, S., Seifert, K., & Gilbert, I. H. (2010). Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis. Bioorganic and Medicinal Chemistry, 18(7), 2559–2565. https://doi.org/10.1016/j.bmc.2010.02.043

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