Wave propagation of cortical population activity under urethane anesthesia is state dependent

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Abstract

Background: Propagating waves of excitation have been observed extensively in the neocortex, during both spontaneous and sensory-evoked activity, and they play a critical role in spatially organizing information processing. However, the state-dependence of these spatiotemporal propagation patterns is largely unexplored. In this report, we use voltage-sensitive dye imaging in the rat visual cortex to study the propagation of spontaneous population activity in two discrete cortical states induced by urethane anesthesia.Results: While laminar current source density patterns of spontaneous population events in these two states indicate a considerable degree of similarity in laminar networks, lateral propagation in the more active desynchronized state is approximately 20% faster than in the slower synchronized state. Furthermore, trajectories of wave propagation exhibit a strong anisotropy, but the preferred direction is different depending on cortical state.Conclusions: Our results show that horizontal wave propagation of spontaneous neural activity is largely dependent on the global activity states of local cortical circuits. © 2013 Wanger et al.; licensee BioMed Central Ltd.

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Wanger, T., Takagaki, K., Lippert, M. T., Goldschmidt, J., & Ohl, F. W. (2013). Wave propagation of cortical population activity under urethane anesthesia is state dependent. BMC Neuroscience, 14. https://doi.org/10.1186/1471-2202-14-78

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