Wilson's disease in pregnancy: Case series and review of literature

Citations of this article
Mendeley users who have this article in their library.


BACKGROUND: Wilson's disease is a rare, autosomal recessive inherited disorder characterized by impaired liver metabolism of copper leading to decreased biliary excretion and incorporation of ceruloplasmin levels mainly in the liver and brain. Untreated Wilson's disease has been shown to cause subfertility and even in cases where pregnancy occurs, it often results in spontaneous miscarriage.<br /><br />CASE PRESENTATIONS: We present four cases of successful pregnancy outcomes in three patients diagnosed with Wilson's disease along with the literature review. All the patients were managed with zinc sulphate without any postnatal complications.<br /><br />CONCLUSION: Patients with Wilson's disease receiving regular treatment who remain asymptomatic are usually able to conceive and achieve successful outcomes. However, these pregnancies should be considered high risk and merit regular surveillance.




Malik, A., Khawaja, A., & Sheikh, L. (2013). Wilson’s disease in pregnancy: Case series and review of literature. BMC Research Notes, 6(1). https://doi.org/10.1186/1756-0500-6-421

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free