Frizzled receptors can activate two alternative signal transduction pathways: the canonical Wnt pathway or the planar cell polarity pathway. Recent studies of the Naked cuticle protein suggest a mechanism for the inactivation of the canonical pathway and concomitant activation of the planar cell polarity pathway.
McEwen, D. G., & Peifer, M. (2001, July 10). Wnt signaling: The naked truth? Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(01)00310-4