WS16.3 Vitamin D supplementation in patients with cystic fibrosis: A pilot randomized controlled trial

  • Pincikova T
  • Flodström-Tullberg M
  • Hjelte L
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Objectives: Vitamin D (vit D) insufficiency is frequent in CF patients. Evidence of benefit of vit D in CF is weak. The effect of vit D on calcium homeostasis, inflammation, lung function and quality of life in CF patients was investigated in a pilot trial ( Methods: Patients (16) were randomized to vit D2 or vit D3 or to serve as controls. The initial weekly dose of 35000/50000 IU (children/adults) was individually adjusted by monitoring s25OHD. Three months of intervention were followed by two of wash-out. Results: S25OHD correlated with total vit D dose/kg BW, and with sun exposure. Patients on vit D3 had a transitory increase in albumin-corrected calcium at 1-week visit and higher s25OHD compared with controls at 3-months visit. In this group, serum IgA increased, eosinophils decreased and there was a tendency for decrease in IL-6 and CRP. Patients receiving vit D2 downregulated serum total IgG and upregulated lymphocytes. Patients reaching s25OHD 111-129 nmol/l increased their PEF, FEF25% and CFQ-R self-reported scores in the Emotion, Body, Weight and Respiratory domains. The CFQ-R parent-reported score for the Respiratory domain was higher in children reaching s25OHD 92-97 nmol/L compared with those reaching s25OHD 58-82 nmol/l. Accordingly, s25OHD correlated positively with FEV%, FEF50%, FEF75%, and CFQ-R scores for the Emotion and Respiratory domains. No vit D toxicity was seen. Conclusion: Our results suggest that vit D supplementation in CF patients is safe and beneficial. Its effect may be clinically relevant when s25OHD is increased to 111-129 nmol/L, with positive impact on inflammation, lung function and quality of life




Pincikova, T., Flodström-Tullberg, M., & Hjelte, L. (2013). WS16.3 Vitamin D supplementation in patients with cystic fibrosis: A pilot randomized controlled trial. Journal of Cystic Fibrosis, 12, S32.

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